YouGottaPractice on Instagram: "Explanation: • A. ❌ CIN – Associated with APC mutations, not MLH1. • B. ✅ MSI – Loss of MLH1 → mismatch repair defect → hallmark of MSI. • C. ❌ CIMP – Involves promoter methylation, can silence MLH1 but MSI is the actual phenotype. • D. ❌ p53 – Late event in adenoma-carcinoma sequence, unrelated to MLH1 loss."

med's go on Instagram: "Lynch syndrome, also known as hereditary nonpolyposis colorectal cancer (HNPCC), is caused by germline mutations in DNA mismatch repair (MMR) genes—most commonly MLH1, MSH2, MSH6, and PMS2. These mutations lead to microsatellite instability (MSI), a hallmark feature of the syndrome. It is inherited in an autosomal dominant manner and significantly increases the risk of colorectal cancer, particularly in the proximal colon, as well as other cancers, including endometrial,

Zion Ko Lamm, M.D. (고시온) on Instagram: "It’s Hereditary Cancer Awareness Week so i wanted to share our story. My dad was diagnosed with colon cancer in his early 30s. Since then, he’s had stomach cancer, duodenal cancer (s/p Whipple) and now new GI cancer. That’s what Lynch syndrome looks like. When my brother and I were in our 20s, we decided to get tested together. I’ll never forget finding out during residency that I carry the MLH1 mutation. I was devastated. A genetic counselor helped me