OXPHOS inhibitors, metabolism and targeted therapies in cancer
May 1, 2023 · This review focuses on classical and promising OXPHOS inhibitors (OXPHOSi), unravelling their interest and modes of actions in cancer, particularly in combination with other …
Why All the Fuss about Oxidative Phosphorylation (OXPHOS)?
Increased OXPHOS dependency is frequently a hallmark of cancer stem cells and cells resistant to chemotherapy and targeted therapies. Suppressing the OXPHOS function might also …
Complex I inhibitor of oxidative phosphorylation in advanced …
Jan 19, 2023 · Although targeting oxidative phosphorylation (OXPHOS) is a rational anticancer strategy, clinical benefit with OXPHOS inhibitors has yet to be achieved.
Oxidative Phosphorylation as an Emerging Target in Cancer Therapy
May 31, 2018 · Several drugs including metformin, atovaquone, and arsenic trioxide are used clinically for non-oncologic indications, but emerging data demonstrate their potential use as …
OXPHOS-targeting drugs in oncology: New perspectives - PMC
A new class of OXPHOS-targeting drugs is emerging as a potential cancer therapeutic. One of the OXPHOS inhibitor drugs, IACS-010759, developed by investigators at MD Anderson Cancer …
Inhibition of OXPHOS induces metabolic rewiring and reduces …
OXPHOS inhibition reduces tumor hypoxia in tumor spheroids and in vivo. Caution is warranted as systemic metabolic rewiring can cause adverse effects. OXPHOS is a potential therapeutic …
An inhibitor of oxidative phosphorylation exploits cancer
Treatment with IACS-010759 robustly inhibited proliferation and induced apoptosis in models of brain cancer and acute myeloid leukemia (AML) reliant on OXPHOS, likely owing to a …
Targeting mitochondrial oxidative phosphorylation: lessons, …
Aug 10, 2023 · More specifically, as dependencies on oxidative phosphorylation (OXPHOS) appear prevalent in a variety of aggressive cancer types, the development of OXPHOS …
OXPHOS-targeting drugs in oncology: new perspectives
Several classes of drug molecules selectively target cancer cell mitochondria and inhibit mitochondrial respiration or oxidative phosphorylation (OXPHOS). A new class of OXPHOS …
An inhibitor of oxidative phosphorylation exploits cancer ... - Nature
Jun 11, 2018 · A new inhibitor targeting the mitochondrial complex I shows antitumor activity in preclinical models of acute myeloid leukemia and glioblastoma relying on oxidative …