Interleukin 4 - Wikipedia
The interleukin 4 (IL4, IL-4) is a cytokine that induces differentiation of naive helper T cells (T h 0 cells) to T h 2 cells. Upon activation by IL-4, T h 2 cells subsequently produce additional IL-4 in a positive …
Department of Defense (DoD) Impact Level 4 (IL4)
What Azure services are covered by DoD IL4 PA and in what regions? To find out what services are available in Azure Government, see Products available by region.
Interleukin-4: A Cytokine to Remember - PMC
Although this review focuses on its neurological functions, most of what is known about IL4 comes from studies of peripheral immune cells, such as macrophages and lymphocytes. Therefore, in discussing …
IL4 Gene - GeneCards | IL4 Protein | IL4 Antibody
Nov 13, 2025 · IL4 is considered an important cytokine for tissue repair, counterbalancing the effects of proinflammatory type 1 cytokines, however, it also promotes allergic airway inflammation.
IL4 Signaling: Pathways, Receptors, and Immune Functions
Genetic polymorphisms in IL4 and IL4R genes have been linked to allergic disorder susceptibility. Targeting IL-4 signaling has led to therapies like dupilumab, a monoclonal antibody that blocks IL …
Interleukin 4 - an overview | ScienceDirect Topics
IL-4 receptors (IL-4R) are also overexpressed in multiple cancer types, including GBM, rendering them as a conceivable cancer biomarkers and therapeutic targets.65 For instance, it has been shown that …
Interleukin 4, Serum - Cytokine Panel 13, Serum | Healthmatters.io
Interleukin-4 (IL4) is a growth factor for both B and T lymphocytes. - High levels of IL4Rs have been observed on tumors derived from such cells. - IL4Rs are also overexpressed on activated T …
THE IL-4 RECEPTOR: Signaling Mechanisms and Biologic Functions
Abstract Interleukin-4 is a multifunctional cytokine that plays a critical role in the regulation of immune responses. Its effects depend upon binding to and signaling through a receptor complex consisting of …
Recent advances in understanding the role of IL-4 signaling
Sep 7, 2021 · Interleukin-4 (IL-4) is a four-α-helical bundle type I cytokine with broad pleiotropic actions on multiple lineages. Major actions of IL-4 were initially discovered for B and T cells, but this cytokine …
Healing action of Interleukin-4 (IL-4) in acute and chronic ...
Jan 1, 2025 · Upon intravenous injection into non-obese diabetic mice, the pCMV-IL4-IL10/PAGA complex effectively ameliorated pancreatic islet inflammation and reduced the incidence of …