Upon steroid binding, the androgen receptor (AR) undergoes a conformational change and releases heat-shock proteins (hsps). Phosphorylation (P) occurs before or after steroid binding. The AR …

The Androgen Receptor (AR), transcriptionally activated by its ligands, testosterone and dihydrotestosterone (DHT), is widely expressed in cells and tissues, influencing normal biology and …

The predominant mode of androgen action is through binding in target tissues to a specific receptor termed the androgen receptor. This receptor can regulate the expression of a set of androgen …

The androgen receptor is a member of a superfamily of nuclear transcription factors that mediate the action of steroid hormones. When activated by ligand binding, these transcription factors bind to …

Aug 9, 2025 · Androgens, vital for male sexual development and behavior, function through the androgen receptor (AR), a transcription factor controlled by testosterone and 5α-dihydrotestosterone.

Androgen Receptor—A Key Driver of PCa and Drug Target. The differentiation and development of the prostate is dependent upon the androgen dihydrotestosterone (DHT), which can be derived directly …

In this review, the types of androgens, their functions and signaling are tabulated and described, including some less-known functions.

Androgens (also called androgenic hormones), such as testosterone or dihydrotestosterone, are understood to exert their primary effects through binding to an androgen receptor in the cytosol.

Androgen receptor (AR) belongs to the steroid hormone receptor family of the nuclear receptor superfamily and acts as a hormone-controlled transcription factor that conveys the messages of both …

The AR gene provides instructions for making a protein called an androgen receptor. Androgens are hormones (such as testosterone) that are important for normal male sexual development before birth …