BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) has become the most prevalent type of heart failure, but ...

This is due to their lack of affinity for HSPG (16). The FGFR family comprises four members, FGFR1-4, which are highly conserved tyrosine kinase transmembrane receptors (RTKs). Additionally, there is ...

A research team at the University of Cologne discovered that the 1N4R tau protein isoform plays a key role in Alzheimer’s disease by mediating the toxic effects of protein clumps in brain cells. Using ...

"The preliminary results of that study, which is a phase 1/2 dose escalation and dose expansion trial, were presented by Professor Ben Tran last year at the ENA meeting1 and showed a very favorable ...

The authors provide convincing evidence indicating that two receptor tyrosine kinases (RTKs), CAD96CA and FGFR1, modulate the genomic effects of JH by phosphorylating the intracellular receptors in ...

In this important study, Li and others identified cell membrane receptors for juvenile hormone (JH), a terpenoid hormone in insects that regulates their development and reproduction. While ...

Tyra Biosciences' TYRA-300, an oral FGFR3 inhibitor, showed promising efficacy but raised concerns with some FGFR1/2-driven adverse events, causing a significant stock drop. TYRA-300 demonstrated ...

Using human induced pluripotent stem cells (iPSCs), the international team has been able to show that a specific form of the tau protein, known as the 1N4R isoform, is responsible for mediating ...