This study reports two cryo-EM structures of the Nipah virus (NiV) polymerase L-P complex in its full-length and truncated ...

This valuable study presents an analysis of evolutionary conservation in intrinsically disordered regions, identified as key drivers of phase separation, leveraging a protein language model. The ...

All-atom simulations show that hydroxyl groups in alkanediols mediate interactions with the protein backbone and polar amino acid side chains, while the aliphatic chain allows contact with hydrophobic ...

School of Chemical Sciences, National Institute of Science Education and Research (NISER), PO- Bhimpur-Padanpur, Via-Jatni, District- Khurda, Bhubaneswar PIN 752050, India ...

GitHub Repository associated with the piQTL project (Mapping effects of genome-wide genetic variation to protein-protein interactions reveals molecular mechanisms of complex traits) [ Serohijos & ...

In a study published in the Journal of the American Chemical Society, scientists explore how a brain protein called ... driven by electrostatic and hydrophobic interactions. Remarkably, the ...

School of Chemical and Process Engineering, University of Leeds, Leeds LS2 9JT, U.K. Food Colloids and Bioprocessing Group, School of Food Science and Nutrition, University of Leeds, Leeds LS2 9JT, ...

New research pioneered by The University of Western Australia is shedding light on the intricate dance between proteins ... plasticity of the coiled–coil interactions in human SFPQ, Nucleic ...

Therefore, locally, protein-water interactions are strongly influenced by the chemistry of side chains, and water molecules have fewer hydrogen bonding opportunities with more hydrophobic residues.

To execute different functions inside cells, paralogs often acquire different specificities, interacting with desired, cognate partners and avoiding cross-talk with noncognate proteins. But how robust ...