Although many ecDNA-encoded oncogenes and their protein products, such as epidermal growth factor receptor (EGFR) and fibroblast growth factor receptor 1 (FGFR1), are validated drug targets for ...

Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences, Oncological Sciences and Neuroscience, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York ...

In mammals, the fibroblast growth factor (FGF)-FGF receptor (FGFR) interactions control many physiological processes during development and life. Impaired FGFR signaling has been associated with ...

Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266071, China ...

This fundamental article significantly advances our understanding of FGF signalling, and in particular highlights the complex modifications affecting this pathway. The evidence for the authors' claims ...

Heart failure with preserved ejection fraction (HFpEF) has become the most prevalent type of heart failure, but effective treatments are lacking. Cardiac lymphatics play a crucial role in maintaining ...

Ask yourself, what is necessary for you to read this article? And how are you able to discern between individual words or letters? Evolution has solved these challenges by developing a complex organ, ...