The Bills beat the Patriots 24-21 thanks to the performance from starting running back James Cook along with timely plays made by the defense. Cook ran the ball 11 times for 100 yards and one touchdown while also catching three passes for 26 yards and another touchdown, showing his ability to affect the game on the ground and through the air.

Buffalo Bills running back James Cook has had a massive breakout season. Entering the game against the Patriots, Cook had 828 rushing yards at 4.8 yards per carry and 13 rushing touchdowns, adding 232 receiving yards and a touchdown through the air as well.

ORCHARD PARK, N.Y. -- Running back James Cook got the Buffalo Bills on the board with a 46-yard rushing touchdown in the second quarter to cut the New England Patriots' lead in half. The touchdown drive came after a sluggish start for the Bills.

Buffalo has talented players on both sides of the ball, as they are one of the most dominant teams in the AFC. Running back James Cook would be a perfect addition to the Patriots’ backfield, so he is my pick for this week’s Gimme Him player.

Josh Allen doesn't have to do it all, and may be hard-pressed to top 4,000 yards passing for a fifth consecutive season. And that’s not a bad thing.

In Sunday’s 24-21 victory over the New England Patriots, the Bills trotted out a new personnel grouping for the first time this season.

The Buffalo Bills won a nail-biter against the New England Patriots, 24-21, in Week 16 action. The Bills, a massive 14.5-point favorite entering the game, struggled mightily to dominate their lowly divisional rivals.

Buffalo Bills' running back James Cook breaks away from the New England Patriots' defense on an explosive 46-yard touchdown run. Dallas Cowboys cornerback DaRon Bland yanks a game-sealing takeaway from Tampa Bay Buccaneers running back Rachaad White's grasp.

Watch the best plays from Buffalo Bills running back James Cook's 2-touchdown game vs. the New England Patriots in Week 16 of the 2024 NFL season.

A whole lot of running back James Cook and takeaways by the defense helped the Buffalo Bills erase an early 14-point deficit Sunday against the New England Patriots.

James Cook will lead the Buffalo Bills into their game versus the New England Patriots at Highmark Stadium on Sunday at 4:25 p.m. ET.The Patriots have been sputtering offensively, ranking