Hepatic glucose metabolism encompasses several catabolic and anabolic fluxes that have distinct modes of hepatocyte-autonomous (direct) and hepatocyte- non-autonomous (indirect) regulatory mechanisms ...

Mammalian cells use glucose as a major energy source; certain cell types such as neurons and red blood cells are especially dependent on glucose. Homeostatic mechanisms are in place to maintain blood ...

Activated SIK2 prevents the proper binding of TORC2 with CREB, turning off blood sugar production. Insulin affects the ability of the TORC2 protein to bind to CREB, which in turn produces the blood ...