The Week 6 NFL schedule has a bit of everything with the biggest NFL spread of the season, a potential Super Bowl preview on Sunday night and a two-game slate on Monday. Packers vs. Browns has Green Bay as 14.5-point favorites, per the Week 6 NFL odds ...

CINCINNATI BENGALS at PITTSBURGH STEELERS (-5.5) … PICK: Steelers -5.5 TAMPA BAY BUCCANEERS at BUFFALO BILLS (-6.5) … PICK: Buccaneers +6.5 HOUSTON TEXANS (-5.5) at TENNESSEE TITANS … PICK: Texans -5.5 SAN FRANCISCO 49ERS (-3.5) at ARIZONA CARDINALS … PICK: Cardinals +3.5

Full NFL picks for every game with predictions straight-up and against the spread, from the KC-Denver showdown to the Seattle-LA clash.

Expert recap and game analysis of the Jacksonville Jaguars vs. Los Angeles Chargers NFL game from November 16, 2025 on ESPN.