More information: Meirui An et al, In vivo base editing extends lifespan of a humanized mouse model of prion disease, Nature ...

These organoids, aside from saving time and animal lives, should also more accurately model how prions make ... chief of the Prion Cell Biology Unit at NIAID’s Laboratory of Neurological ...

There is no model which we can use to compare ... the normal brain cells can be infected, make prions and become diseased, but the neighboring cells from the PrP knockout host can not.

Accumulation of a protein called TDP-43 is a key feature of ALS and frontotemporal dementia. In a newly published study, ...

Glioblastoma (GBM), one of the most aggressive types of brain cancer, is one of the greatest challenges for medicine, both ...

Julie Moreno, Colorado State University Popichak, who now studies neuroinflammation and glial cell biology at CSU ... 3 A mouse that has been dosed with infectious prions on the other hand, is not ...

In contrast, our studies of the ME7 mouse scrapie model indicate involvement of a particular cell type, the FDC, in TSE replication in lymphoid tissues. For ME7, neuroinvasion also seems closely ...

Researchers have developed a laboratory model that mimics the pathological aggregation of TDP-43, a key protein in ALS and ...

Limitations of the three putative mechanisms of amyloid fibril assembly for explaining Sup35 prion formation have led to the introduction of a fourth model ... normal yeast cells into the ...

However what is not known is how the prions damage brain cells (neurons). For the study, Dr Clive Bate and colleagues from the Royal Veterinary College in the UK compared the amounts of protein ...

White et al. injected anti-PrP monoclonal antibodies with high affinity for both murine PrPC and PrPSc into individual mice from a scrapie model strain. They observed that peripheral PrPSc levels and ...

May 17, 2024 — A new study of prion diseases, using a human cerebral organoid model, suggests there is a substantial species barrier preventing transmission of chronic wasting disease (CWD ...