He generated monoclonal antibodies by adopting a technique that used mouse spleens to develop specific antibodies. However, he ran into the same challenges as other researchers with the limited supply ...

The human anti-mouse antibody (HAMA) reaction limits the therapeutic utility of mouse monoclonal antibodies. Humanization of mouse monoclonal antibodies by genetic engineering can improve the in ...

Due to their extraordinary specificity and pharmacokinetic (PK) behavior, human immunoglobulin gamma monoclonal ... engineered human IgG1 antibodies in a humanized FcRn mouse model: potential ...