The properties of aptamers have enabled the development of new anticoagulant agents that block several proteins involved in the coagulation cascade. The most advanced results are obtained with ...

The tide of the blood coagulation cascade turns by a switch in thrombin ... Major clinical indications of such anticoagulants include cardiovascular disorders and thrombosis.

Anticoagulants and antiplatelet agents pose a great risk in patients undergoing surgery. Because these products inhibit at least one, and often multiple, factors in the clotting cascade ...

Patients can receive anticoagulants, such as heparin ... and expression of a tissue factor that initiates the coagulation ...

Oral anticoagulants that require no monitoring ... small molecules to directly inhibit the two key proteases in the coagulation cascade: thrombin and factor Xa (FXa). The recent approval of ...