In the landmark Amgen v. Sanofi case (previously covered here), the Supreme Court affirmed that patent claims drawn to a genus of ...

where diverse natural CDRs are combined into an antibody framework 11, using only CDR-encoding gene fragments originating from sequences formed and “proofread” in vivo. Such proofread peptide ...

Paratope-PLUS™ involves mutating each residue of an antibody's CDRs (Complementarity Determining Regions) to all 19 other amino acids, identifying every variant that retains or enhances function.