Arizona had the passing game working, but it didn't matter in a 41-22 loss to San Francisco at State Farm Stadium in Glendale.

The Arizona Cardinals are searching for answers after a second straight embarrassing loss to an NFC West rival.

Arizona Cardinals head coach Jonathan Gannon says talk of him being on the 'hot seat' as far as his job comes with being an NFL head coach.

San Francisco 49ers tight end George Kittle (85) catches a touchdown pass in front of Arizona Cardinals linebacker Akeem Davis-Gaither (27) during the first half of an NFL football game in Glendale, Ariz., Sunday, Nov. 16, 2025. Credit: AP/Ross D. Franklin

Oct 6, 2024; Santa Clara, California, USA; San Francisco 49ers tight end George Kittle (85) gestures after a catch against the Arizona Cardinals during the fourth quarter at Levi's Stadium. Mandatory Credit: Darren Yamashita-Imagn Images / Darren Yamashita-Imagn Images

The Cardinals won the toss and elected to defer, giving the 49ers the first possession of the game. On the opening kickoff, Skyy Moore fielded it and went 98 yards, getting tackled at the one-yard line. On the first play from scrimmage, Christian McCaffrey went one yard for the touchdown.

Bam Knight is active for the Arizona Cardinals' Week 11 game against the San Francisco 49ers and will likely lead the backfield, as he has recently.

The Cardinals' WR corps takes another hit. Zay Jones is done for the season and Marvin Harrison Jr. has appendicitis.

San Francisco 49ers wide receiver Skyy Moore opens the game against the Arizona Cardinals with a 98-yard kick return.

The Arizona Cardinals have a lengthy injury report ahead of Week 11, with seven players officially ruled out against the San Francisco 49ers.