Cardinals, 49ers
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San Francisco 49ers kicker Eddy Piñeiro and linebacker Tatum Bethune have been standouts as in-season substitutes, but both will miss several games after injuries sustained against the Cardinals.
Brock Purdy came through the Arizona game healthy, but kicker Eddy Piñeiro and linebacker Tatum Bethune did not.
Carolina is coming off a huge emotional win over Atlanta, but a much tougher opponent is lurking next on the schedule.
San Francisco 49ers head coach Kyle Shanahan provided an unfortunate injury return timeline update for Brandon Aiyuk.
Brock Purdy still believes the San Francisco 49ers can return to the NFL playoffs and make a run at a Super Bowl ring despite their injuries.
The 49ers drafted Martin to play their WILL spot, which is the weakside linebacker spot. This is the position Dee Winters plays, not Warner and Bethune. Warner played the MIKE, which is in the middle, and gets the defense aligned. The WILL is more about run-and-chase. They are asked to do different things.
Kyle Shanahan said Brock Purdy "checked out all right" after his first game back. Linebacker Tatum Bethune, however, didn't fare as well.
SANTA CLARA, Calif. (AP) — Brock Purdy returned to the lineup and the San Francisco 49ers scored their most points in nearly two years. While Purdy looked sharp in the 41-22 victory over the Arizona Cardinals on Sunday, the reasons behind the big scoring output have to do with a lot more than just the change at quarterback.
Arizona had the passing game working, but it didn't matter in a 41-22 loss to San Francisco at State Farm Stadium in Glendale.
The 49ers' team captains stepped up in Arizona. One of them, George Kittle, said the team is positioned right where it needs to be.
Head coach Kyle Shanahan of the San Francisco 49ers looks on during warmups before the game against the Arizona Cardinals at State Farm Stadium on Nov. 16, 2025 in Glendale, Ariz. A costly penalty by a San Francisco 49ers defensive player led head coach Kyle Shanahan to bench him and confront him on the sidelines.
Ever since training camp last year, the San Francisco 49ers have been hit with one injury to a key player after another. They haven't gotten any type of respite from the injury bug, and it resulted in them going 6-11 and missing the playoffs last season after coming off a narrow loss in Super Bowl LVIII.